United States securities and exchange commission logo November 27, 2020 Steven C. Quay Chairman, Chief Executive Officer and President Atossa Therapeutics, Inc. 107 Spring Street Seattle, WA 98104 Re: Atossa Therapeutics, Inc. Registration Statement on Form S-1 Filed November 20, 2020 File No. 333-250820 Dear Mr. Quay: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact David Gessert at 202-551-2326 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences